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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EPS8
All Species:
17.58
Human Site:
S459
Identified Species:
48.33
UniProt:
Q12929
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12929
NP_004438.3
822
91882
S459
D
L
Y
Q
L
A
E
S
V
A
N
V
A
E
H
Chimpanzee
Pan troglodytes
XP_528750
1001
111581
F647
W
E
P
P
M
L
N
F
M
G
A
T
M
E
Q
Rhesus Macaque
Macaca mulatta
XP_001091077
1055
116825
S684
D
L
Y
Q
L
A
E
S
V
A
N
V
A
E
H
Dog
Lupus familis
XP_534881
791
88639
S429
D
F
Y
Q
L
A
E
S
V
A
N
V
A
E
H
Cat
Felis silvestris
Mouse
Mus musculus
Q08509
821
91720
S459
D
M
Y
Q
L
A
E
S
V
A
N
A
E
H
Q
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_416405
831
92642
S462
E
L
N
N
L
A
E
S
V
A
N
F
A
E
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_956536
804
88650
R442
D
V
T
Q
L
A
E
R
L
N
A
A
Q
S
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_392229
880
100126
Q436
K
R
D
E
L
P
E
Q
Q
N
D
S
Y
Y
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_785396
970
107261
S605
N
N
A
S
V
A
A
S
A
A
A
V
A
R
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.7
76.1
91.1
N.A.
88.9
N.A.
N.A.
N.A.
79.7
N.A.
51.8
N.A.
N.A.
28.8
N.A.
25.5
Protein Similarity:
100
79
77.1
93.4
N.A.
94.8
N.A.
N.A.
N.A.
88.5
N.A.
66.9
N.A.
N.A.
47.2
N.A.
42.3
P-Site Identity:
100
6.6
100
93.3
N.A.
66.6
N.A.
N.A.
N.A.
66.6
N.A.
33.3
N.A.
N.A.
13.3
N.A.
33.3
P-Site Similarity:
100
20
100
93.3
N.A.
73.3
N.A.
N.A.
N.A.
73.3
N.A.
46.6
N.A.
N.A.
33.3
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
12
0
0
78
12
0
12
67
34
23
56
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
56
0
12
0
0
0
0
0
0
0
12
0
0
0
0
% D
% Glu:
12
12
0
12
0
0
78
0
0
0
0
0
12
56
23
% E
% Phe:
0
12
0
0
0
0
0
12
0
0
0
12
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
34
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
34
0
0
78
12
0
0
12
0
0
0
0
0
0
% L
% Met:
0
12
0
0
12
0
0
0
12
0
0
0
12
0
0
% M
% Asn:
12
12
12
12
0
0
12
0
0
23
56
0
0
0
12
% N
% Pro:
0
0
12
12
0
12
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
56
0
0
0
12
12
0
0
0
12
0
34
% Q
% Arg:
0
12
0
0
0
0
0
12
0
0
0
0
0
12
0
% R
% Ser:
0
0
0
12
0
0
0
67
0
0
0
12
0
12
0
% S
% Thr:
0
0
12
0
0
0
0
0
0
0
0
12
0
0
0
% T
% Val:
0
12
0
0
12
0
0
0
56
0
0
45
0
0
0
% V
% Trp:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
45
0
0
0
0
0
0
0
0
0
12
12
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _